Arne F. Meyer, John O’Keefe, Jasper Poort

(A) Horizontal positions of the two eyes (bottom), angular head yaw position (middle), and gaze (head + eye, top) during 12-s segment in a freely moving mouse selected to highlight the saccade and fixate pattern. Small-amplitude, jerky eye movements and large-amplitude, smooth head movements combine to produce the saccade and fixate gaze pattern.

(B) Magnified traces for a single gaze shift from the recording in (A). Head movement is accompanied by an initial counter-rotation of the eye before the gaze saccade. Vertical and horizontal gray bars indicate saccade and pre/post periods, respectively.

(C) Gaze shift-aligned head and eye velocity traces for clockwise (CW, left) and counter-clockwise (CCW, right) gaze shifts. 44,396 gaze shifts from 5 mice (22,226 CW and 22,170 CCW); mean ± SEM (smaller than line width).

(D) Relation between horizontal eye and head velocity during stabilization periods (example period marked in A). Eye movements between saccadic gaze shifts counteract head rotations; mean ± SEM (smaller than line width). Dashed line indicates complete offsetting counter-rotation; same data as in C.

(E) The same as in (D) but for humans wearing head-mounted eye goggles.

(F) Illustration of monocular left and right visual field (about 180°) and horizontal binocular overlap.

(G) Left: distribution of the difference in right and left eye velocity during stabilizing eye movements (CCW head rotation); mean ± SEM for 5 mice. Right: illustration of consequence of asymmetric nasal-to-temporal and temporal-to-nasal eye velocity on binocular overlap (increase relative to setting shown in F). At the same time, gaze stabilization is enhanced for the left eye during leftward turn.

(H) The same as in (G) but for CW head rotations. Enhanced gaze stabilization for the right eye for mouse turning to the right.

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