Benjamin R. Troutwine, Paul Gontarz, Mia J. Konjikusic, Ryoko Minowa, Adrian Monstad-Rios, Diane S. Sepich, Ronald Y. Kwon, Lilianna Solnica-Krezel, Ryan S. Gray

Adolescent idiopathic scoliosis (AIS) is a common disorder causing curvature of the spine. Despite accumulating evidence pointing to its heritable nature, the underlying genetic causes of AIS are thought to be complex and heterogeneous and thus far are not well established. Zebrafish mutants in motile cilia components with disruption of cerebrospinal fluid (CSF) flow also demonstrate scoliosis, resembling AIS [

  • Konjikusic M.J.
  • Yeetong P.
  • Boswell C.W.
  • Lee C.
  • Roberson E.C.
  • Ittiwut R.
  • Suphapeetiporn K.
  • Ciruna B.
  • Gurnett C.A.
  • Wallingford J.B.
  • et al.
Mutations in kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development.