Benedict Tan, Siti Maryam J.M. Yatim, Suat Peng, Jayantha Gunaratne, Walter Hunziker, Alexander Ludwig
Tan et al. use imaging and proteomics to dissect the spatio-molecular organization of the apical-lateral border in mammalian epithelial cells. The authors resolve the apical junctional complex and uncover a novel polarity domain apical of tight junctions that is defined by the Crumbs complex.